Table 2.
Mendelian randomisation (MR) sensitivity analyses
| Analysis | Two-sample | One-sample | |||
|---|---|---|---|---|---|
| Estimate (95% CI) | P value | Estimate (95% CI) | P value | ||
| Education-coronary heart disease | |||||
| IVW | 0.63 (0.60 to 0.67) | <0.001 | 0.51 (0.26 to 1.00) | 0.05 | |
| MR-Egger | 0.68 (0.54 to 0.85) | 0.001 | 0.54 (0.12 to 2.34) | 0.41 | |
| MR-Egger intercept | NA | 0.37 | NA | 0.93 | |
| Weighted median | 0.62 (0.57 to 0.67) | <0.001 | 0.98 (0.96 to 0.99) | 0.33 | |
| Education-stroke | |||||
| IVW | 0.71 (0.68 to 0.75) | <0.001 | 0.46 (0.30 to 0.71) | <0.001 | |
| MR-Egger | 0.72 (0.60 to 0.87) | 0.001 | 0.57 (0.22 to 1.47) | 0.25 | |
| MR-Egger intercept | NA | 0.76 | NA | 0.60 | |
| Weighted median | 0.71 (0.66 to 0.76) | <0.001 | 0.99 (0.98 to 1.00) | 0.002 | |
| Education-myocardial infarction | |||||
| IVW | 0.61 (0.58 to 0.65) | <0.001 | 0.18 (0.08 to 0.38) | <0.001 | |
| MR-Egger | 0.67 (0.52 to 0.85) | 0.001 | 0.20 (0.04 to 1.03) | 0.05 | |
| MR-Egger intercept | NA | 0.39 | NA | 0.88 | |
| Weighted median | 0.59 (0.54 to 0.65) | <0.001 | 0.99 (0.98 to 1.00) | 0.002 | |
| Education-cardiovascular disease | |||||
| IVW | NA | NA | 0.64 (0.51 to 0.82) | <0.001 | |
| MR-Egger | NA | NA | 0.57 (0.34 to 0.95) | 0.03 | |
| MR-Egger intercept | NA | NA | NA | 0.59 | |
| Weighted median | NA | NA | 0.96 (0.94 to 0.98) | <0.001 | |
| Education-BMI | |||||
| IVW | −0.22 (−0.24 to −0.20) | <0.001 | −0.36 (−0.49 to −0.23) | <0.001 | |
| MR-Egger | −0.28 (−0.49 to −0.07) | 0.009 | −0.15 (−0.41 to 0.12) | 0.29 | |
| MR-Egger intercept | NA | 0.99 | NA | 0.08 | |
| Weighted median | −0.27 (−0.30 to −0.23) | <0.001 | −0.51 (−0.62 to −0.39) | <0.001 | |
| Education-systolic blood pressure | |||||
| IVW | −0.15 (−0.17 to −0.14) | <0.001 | −0.14 (−0.24 to −0.04) | 0.005 | |
| MR-Egger | −0.13 (−0.21 to −0.05) | 0.002 | −0.10 (−0.30 to 0.11) | 0.37 | |
| MR-Egger intercept | NA | 0.32 | NA | 0.65 | |
| Weighted median | −0.18 (−0.21 to −0.16) | <0.001 | −0.12 (−0.21 to −0.03) | 0.008 | |
| Education-smoking | |||||
| IVW | −0.32 (−0.33 to −0.31) | <0.001 | −0.37 (−0.47 to −0.28) | <0.001 | |
| MR-Egger | −0.29 (−0.36 to −0.22) | <0.001 | −0.40 (−0.60 to −0.20) | <0.001 | |
| MR-Egger intercept | NA | NA | NA | 0.73 | |
| Weighted median | −0.35 (−0.37 to −0.33) | <0.001 | −0.37 (−0.46 to −0.29) | <0.001 | |
IVW=inverse-variance weighted; NA=not applicable
Coronary heart disease, stroke, and myocardial infarction are in odds ratio units. BMI, systolic blood pressure, and smoking behaviour are in standard deviation units. In one-sample analyses, the weighted median was estimated on the risk difference scale and converted to odds ratio by using linear combinations.