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. 2019 May 15;10:441. doi: 10.3389/fgene.2019.00441

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Copyright © 2019 Liu, Zheng, Sheng, Kong, Jiang, Yang, Han, Cheng, Zhang and Han.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Flow diagram of ICDS methodology. (A) Calculated risk score of genes (RS) in cancer by considering three types of genetic molecular features: gene expression, CNV and DNA methylation. (B) Combine gen-risk score with pathway topological structure to infer the subpathway activity score (AS); subpathways with discriminative activity score in cancer were identified via a greedy search algorithm. (C) A permutation test is performed on the risk score of genes, and pathways are prioritized by FDR after permutation tests.