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. 2019 May 15;10:441. doi: 10.3389/fgene.2019.00441

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Copyright © 2019 Liu, Zheng, Sheng, Kong, Jiang, Yang, Han, Cheng, Zhang and Han.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Dysfunctional subpathway (path:04020_1) of calcium signaling pathway in CESC. The vertex in the subnetwork represents a gene, and green and purple colors in the vertex represent the proportion of the gene’s differential expression scores and differential methylation scores between cancer samples and normal samples; orange colors represent the proportion of the influence of CNV on gene expression. (B) Annotation of genes in path:04020_1 to the original calcium signaling pathway in KEGG. Genes are marked with red, and the light-yellow circle corresponds to path:04020_1.