. 2019 May 3;30(18):2110–2153. doi: 10.1089/ars.2016.6930

Table 2.

Drugs Protective Against Anthracycline Cardiotoxicity

Treatment	Mechanism	Results
Dexrazoxane	ROS reduction	HF↓
Dexrazoxane	Reduction in DNA damage	HF↓
Statins	Reduction in DNA damage	HF↓
Statins	Reduction in cardiac fibrosis	HF↓
ACE inhibitors	ROS reduction	HF↓
	Reduction in cardiac fibrosis
	Downregulation of NRG1/ErbB pathway
β blockers	Downregulation of catecholamine stimulation	HF↓
β blockers	Enhanced lusitropy	HF↓

Modified from Madonna et al. (232).

ACE, angiotensin-converting enzyme; NRG1, neuregulin 1; ROS, reactive oxygen species.