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. 2019 May 22;39(21):3996–4008. doi: 10.1523/JNEUROSCI.0151-19.2019

Figure 5.

Figure 5.

NAc Drd1-expressing neurons control aggression self-administration and aggression seeking. A, A schematic of the breeding approach used to generate D1-Cre or D2-Cre F1 hybrid mice. B, Mean latency to first attack bout in resident-intruder screenings of C57, CD-1, C57 × D1-Cre, CD-1 × D1-Cre, C57 × D2-Cre, and CD-1 × D2-Cre mice. F1 hybrids of CD-1 mice show similar latency to attack latencies as CD-1 mice. C, D, D1 hybrid mice were injected with hM4Di or mCherry virus in the NAc. Injection of clozapine, but not vehicle, decreased aggression self-administration and aggression seeking in hM4Di but not mCherry-injected mice. E, F, D2 hybrid mice were injected with hM4Di or mCherry virus in the NAc. There was no effect of clozapine or vehicle on aggression self-administration and aggression seeking in hM4Di or mCherry-injected mice. *p < 0.05. Data are from (Golden et al. 2017b, 2019).