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. 2019 May 3;30(18):2066–2109. doi: 10.1089/ars.2018.7534

FIG. 10.

FIG. 10.

Role of OPA1, the MICOS complex and CV in cristae shaping. (A) Tightening of cristae by OPA1 oligomers. See main text for details. (B) Structural shaping of the MIM by the MICOS complex and CV (arrow indicates potential interactions). Additional MICOS complex subunits (MICs) and further details are presented in the main text and Supplementary Table. This figure was compiled by integrating information from (238, 308, 327, 427). ATAD3A, MIM ATPase; CV, OXPHOS (oxidative phosphorylation) complex V; L-OPA1, long form of OPA1; MIC10, MICOS complex subunit 10; MIC12, MICOS complex subunit 12; MIC19, MICOS complex subunit 19 (or CHCHD3); MIC26, MICOS complex subunit 26; MIC27, MICOS complex subunit 27; MIC60, MICOS complex subunit 60 (or Mitofilin, IMMT); MICOS, mitochondrial contact site and cristae organization; S-OPA1, short form of OPA1; SAM, protein sorting and assembly machinery; TOM, protein translocase of the MOM. Color images are available online.