Core mitochondrial fission and fusion proteins. Domain structure of the nine proteins controlling mitochondrial fission (red) and fusion (green). Each protein is drawn to scale according to its length in AA. Further details are provided in the main text. This figure was compiled by integrating information from (206, 208, 238, 425, 449). G-domain, GTPase domain; GED, GTPase effector domain; MPP, matrix-soluble protein peptidase; HR1, heptad repeat domain 1; HR2, heptad repeat domain 2; MTS, mitochondrial targeting sequence; PH, pleckstrin-homology domain; PRD, proline-rich domain; S1, protease cleavage site 1 for OMA1; S2, protease cleavage site 2 for YME1L; Sp, splice variant; TM, transmembrane domain. Color images are available online.