Table 1.
Autoimmune hepatitis and IgG4-associated autoimmune hepatitis
| Ref. | Chung et al[7] | Umemura et al[8] | Amarapurkar et al[9] | Canivet et al[10] | Aydemir et al[11] |
| Country | Japan | Japan | India | France | Turkey |
| Number of AIH | 26 adults | 60 adults | 40 adults | 28 adults | 40 children |
| Number of IgG4-AIH | 9 (34.6%) | 2 (3.3 %) | 10 (25.0%) | 7 (25.0%) | 6 (15.0%) |
| Diagnostic criteria for IgG4-AIH | > 5 IgG4+ cells/HPF | > 10 IgG4+ cells/HPF | > 5 IgG4+ cells/HPF | > 10 IgG4+ cells/HPF | > 10 IgG4+ cells/HPF |
| Laboratory findings vs cAIH | |||||
| ALT | No difference | No difference | No difference | No difference | No difference |
| ALP | No difference | No difference | No difference | No difference | NA |
| γGTP | No difference | NA | NA | No difference | No difference |
| IgG | Higher | No difference | NA | Higher | No difference |
| IgG4 | No difference | Higher | Higher | NA | NA |
| Presence of ANA | No difference | No difference | NA | No difference | NA |
| Detection rate of pathological findings vs cAIH | |||||
| Portal inflammation | No difference | No difference | NA | NA | No difference |
| Interface hepatitis | No difference | Higher | NA | NA | No difference |
| Lobular hepatitis | Higher | Higher | NA | NA | NA |
| Plasma cell infiltration | Higher | Higher | NA | NA | No difference |
| Eosinophil infiltration | Not detected | No difference | NA | NA | No difference |
| Rosette formation | Higher | Higher | NA | No difference | No difference |
| Bile duct damage | No difference | Lower | NA | NA | NA |
| Degree of Fibrosis vs cAIH | No difference | NA | No difference | No difference | No difference |
| IAIHG score vs cAIH | Higher | No difference | No difference | NA | No difference |
| ALT normalization time after PSL therapy vs cAIH | Shorter | NA | NA | NA | Shorter |
cAIH: Classical autoimmune hepatitis; HPF: High-powered field; NA: Not available; IAIHG: International autoimmune hepatitis group; PSL: Prednisolone.