Table 3.
Colorectal cancer detection: Diagnostic accuracy parameters based on quantitative faecal immunochemical test for haemoglobin threshold concentration and brand (DerSimonian´s method)"
| Variable | Studies (n) | Sensitivity1 | I22 | Specificity1 | I22 | Positive LR3 | I22 | Negative LR3 | I22 | Diagnostic OR3 | I22 | Pa | |
| OC-Sensor, > LoD µg Hb/g faeces | |||||||||||||
| All studies | 4 | 98.2 (96.2-99.3) | 0.0 | 35.8 (34.2-37.3) | 96.1 | 1.55 (1.37-1.75) | 94.2 | 0.07 (0.03-0.14) | 0.0 | 21.41 (10.07-45.5) | 0.0 | 0.6 | |
| OC-Sensor, ≥ 10 µg Hb/g faeces | |||||||||||||
| All studies | 8 | 90.8 (87.9-93.2) | 69.7 | 79.9 (79.1-80.7) | 99.4 | 4.79 (2.96-7.76) | 99.1 | 0.15 (0.09-0.23) | 52.7 | 31.44 (19.50-50.68) | 44.7 | 0.09 | |
| 100% Symptomatic | 4 | 94.4 (91.4-96.6) | 0.0 | 65.9 (64.4-67.4) | 99.3 | 2.97 (1.78-4.95) | 99.0 | 0.10 (0.06-0.15) | 0.0 | 28.49 (17.77-45.67) | 0.0 | 0.6 | |
| Mixed patients | 4 | 83.2 (76.5-88.6) | 44.5 | 88.2 (87.4-89.0) | 96.7 | 7.78 (4.72-12.82) | 95.1 | 0.21 (0.13-0.33) | 30.7 | 35.36 (14.19-88.10) | 71.0 | 0.6 | |
| CRC prevalence ≥ 2.5% | 5 | 91.9 (88.7-94.3) | 76.0 | 69.7 (68.5-71.0) | 99.2 | 3.16 (1.99-5.0) | 98.8 | 0.13 (0.07-0.25) | 66.5 | 23.20 (14.76-36.47) | 20.0 | 0.2 | |
| CRC prevalence < 2.5% | 3 | 86.3 (77.7-92.5) | 48.0 | 90.2 (89.4-91.1) | 72.6 | 9.21 (7.23-11.74) | 55.1 | 0.17 (0.09-0.33) | 26.4 | 52.33 (27.23-100.58) | 10.0 | 0.7 | |
| OC-Sensor, ≥ 15 µg Hb/g faeces | |||||||||||||
| All studies | 5 | 91.0 (87.8-93.6) | 73.3 | 81.8 (80.9-82.7) | 99.7 | 4.77 (2.34-9.71) | 99.4 | 0.15 (0.09-0.25) | 57.3 | 36.64 (20.43-65.71) | 49.7 | 0.04 | |
| 100% Symptomatic4 | 3 | 93.6 (90.2-96.0) | 32.6 | 65.8 (64.1-67.5) | 99.5 | 2.91 (1.46-5.78) | 99.3 | 0.11 (0.07-0.16) | 0.0 | 29.10 (12.74-66.46) | 35.5 | 0.67 | |
| OC-Sensor, ≥ 20 µg Hb/g faeces | |||||||||||||
| All studies | 5 | 90.3 (86.9-93.0) | 75.6(86.9-93.0) | 83.4 (82.5-84.2) | 99.7 | 5.30 (2.47-11.34) | 99.4 | 0.15 (0.09-0.27) | 67.2 | 39.02 (21.48-70.88) | 56.1 | 0.04 | |
| 100% Symptomatic4 | 3 | 92.9 (89.5-95.5) | 26.1 | 68.0 (66.3-69.7) | 99.5 | 3.14 (1.52-6.50) | 99.3 | 0.11 (0.07-0.17) | 0.0 | 29.81 (15.05-59.04) | 29.2 | 0.67 | |
1
Values are expressed as percentages and its 95% confidence interval;
2
Values are expressed as percentages;
3
Values are expressed as absolute numbers and its 95% confidence interval;
4
The studies that comprise the 100% symptomatic subgroup also have colorectal cancer prevalence ≥ 2.5%; Pa: Significance of the threshold effect using the Spearman rank correlation (P < 0.01 is considered statistically significant). I2: Inconsistency index; LoD: Limit of detection; LR: Likelihood ratio; OR: Odds ratio; CRC: Colorectal cancer.