Table 5.
OC-Sensor® diagnostic accuracy parameters for colorectal cancer detection (Threshold 10 µg Hb/g faeces) estimated with DerSimonian vs Bivariate methods
| Variable | Studies (n) | Sensitivity1 | Specificity1 | Positive LR2 | Negative LR2 | Diagnostic OR2 |
| All studies (DS) | 8 | 90.8 (87.9-93.2) | 79.9 (79.1-80.7) | 4.79 (2.96-7.76) | 0.15 (0.09-0.23) | 31.44 (19.50-50.68) |
| All studies (Bv) | 8 | 89.6 (82.7-94.0) | 80.2 (67.2-88.9) | 4.52 (2.73-7.50) | 0.13 (0.08-0.20) | 34.85 (20.74-58.57) |
| 100% Symptomatic (DS) | 4 | 94.4 (91.4-96.6) | 65.9 (64.4-67.4) | 2.97 (1.78-4.95) | 0.10 (0.06-0.15) | 28.49 (17.77-45.67) |
| 100% Symptomatic (Bv) | 4 | 94.1 (90.0-96.6) | 66.0 (47.1-80.9) | 2.77 (1.69-4.55) | 0.09 (0.06-0.14) | 30.93 (16.09-59.45) |
| Mixed patients (DS) | 4 | 83.2 (76.5-88.6) | 88.2 (87.4-89.0) | 7.78 (4.72-12.82) | 0.21 (0.13-0.33) | 35.36 (14.19-88.10) |
| Mixed patients (Bv) | 4 | 85.5 (76.5-91.4) | 89.3 (84.1-93.0) | 8.01 (5.07-12.65) | 0.16 (0.10-0.28) | 49.35 (19.88-122.5) |
| CRC prevalence ≥ 2.5% (DS) | 5 | 91.9 (88.7-94.3) | 69.7 (68.5-71.0) | 3.16 (1.99-5.0 ) | 0.13 (0.07-0.25) | 23.20 (14.76-36.47) |
| CRC prevalence ≥ 2.5% (Bv) | 5 | 91.7 (83.3-96.1) | 69.3 (53.5-81.6) | 2.99 (1.97-4.53) | 0.12 (0.07-0.21) | 24.95 (16.02-38.86) |
| CRC prevalence < 2.5% (DS) | 3 | 86.3 (77.7-92.5) | 90.2 (89.4-91.1) | 9.21 (7.23-11.74) | 0.17 (0.09-0.33) | 52.33 (27.23-100.58) |
| CRC prevalence < 2.5% (Bv) | 3 | 84.9 (73.4-92.0) | 90.5 (89.0-91.9) | 8.96 (7.63-10.53) | 0.17 (0.09-0.30) | 53.77 (26.99-107.11) |
1
Values are expressed as percentages and its 95% confidence interval;
2
Values are expressed as absolute numbers and its 95% confidence interval. Bv: Bivariate; CRC: Colorectal cancer; D: DerSimonian; LR: Likelihood ratio; OR: Odds ratio.