Table 6.
Advanced neoplasia and significant colonic lesion detection: Diagnostic accuracy parameters based on quantitative faecal immunochemical test threshold concentration and brand (DerSimonian´s method)
| Variable | Studies (n) | Sensitivity1 | I22 | Specificity1 | I22 | Positive LR3 | I22 | Negative LR3 | I22 | Diagnostic OR3 | I22 | Pa |
| Advanced neoplasia | ||||||||||||
| OC-Sensor, > LoD µg Hb/g faeces | ||||||||||||
| All studies | 3 | 91.0 (88.7-93.0) | 87.9 | 36.9 (35.0-38.8) | 95.2 | 1.40 (1.35-1.45) | 0.0 | 0.26 (0.16-0.44) | 76.6 | 5.44 (3.48-8.48) | 58 | < 0.001 |
| OC-Sensor, ≥ 10 µg Hb/g faeces | ||||||||||||
| All studies | 5 | 67.9 (65.1-70.5) | 97.4 | 81.0 (80.0-82.0) | 99.5 | 3.42 (1.97-5.94) | 98.8 | 0.41 (0.30-0.57) | 93.4 | 9.43 (8.10-10.98) | 0.0 | < 0.001 |
| 100% Symptomatic | 3 | 79.7 (76.5-82.6) | 94.6 | 67.3 (65.5-69.1) | 99.4 | 2.43 (1.41-4.17) | 98.5 | 0.32 (0.21-0.49) | 86.5 | 8.67 (6.96-10.80) | 5.8 | < 0.001 |
| Prevalence CRC ≥ 2.5% | 4 | 71.7 (68.8-74.5) | 97.1 | 76.7 (75.4-77.9) | 99.5 | 2.96 (1.65-5.30) | 98.9 | 0.36 (0.25-0.53) | 91.8 | 9.29 (7.79-11.09) | 9.3 | < 0.001 |
| OC-Sensor, ≥ 15 µg Hb/g faeces | ||||||||||||
| All studies | 5 | 65.0 (62.2-67.8) | 97.6 | 83.5 (82.5-84.4) | 99.6 | 3.90 (2.04-7.47) | 99.0 | 0.43 (0.31-0.60) | 94.2 | 10.06 (8.14-12.44) | 42.4 | < 0.001 |
| 100% Symptomatic | 3 | 76.8 (73.5-79.9) | 95.6 | 70.3 (68.5-72.1) | 99.4 | 2.63 (1.39-4.97) | 98.8 | 0.34 (0.22-0.52) | 88.4 | 8.88 (7.23-10.91) | 0.0 | < 0.001 |
| Prevalence CRC ≥ 2.5% | 4 | 69.3 (66.3-72.1) | 97.1 | 79.4 (78.2-80.6) | 99.6 | 3.33 (1.67-6.66) | 99.1 | 0.38 (0.27-0.54) | 91.1 | 9.72 (7.46-12.66) | 55.4 | < 0.001 |
| OC-Sensor, ≥ 20 µg Hb/g faeces | ||||||||||||
| All studies | 5 | 62.9 (60.1-65.7) | 97.8 | 85.1 (84.2-86.0) | 99.6 | 4.34 (2.16-8.73) | 99.0 | 0.45 (0.32-0.62) | 95.3 | 10.62 (8.24-13.67) | 57.4 | < 0.001 |
| 100% Symptomatic | 3 | 75.1 (71.7-78.3) | 96.1 | 72.4 (70.7-74.1) | 99.5 | 2.85 (1.43-5.65) | 98.8 | 0.35 (0.23-0.55) | 90.4 | 9.19 (7.47-11.32) | 1.8 | < 0.001 |
| Prevalence CRC ≥ 2.5% | 4 | 67.5 (64.5-70.4) | 97.3 | 81.2 (80.0-82.3) | 99.6 | 3.66 (1.74-7.71) | 99.1 | 0.40 (0.29-0.55) | 91.7 | 10.19 (7.49-13.86) | 66.5 | < 0.001 |
| Significant colonic lesion | ||||||||||||
| OC-Sensor, LoD µg Hb/g faeces | ||||||||||||
| All studies | 3 | 91.7 (89.5-93.6) | 0.0 | 36.9 (35.0-39.0) | 94.2 | 1.45 (1.32-1.59) | 80.4 | 0.24 (0.19-0.30) | 0.0 | 6.01 (4.57-7.92) | 0.0 | < 0.001 |
| OC-Sensor, ≥ 10 µg Hb/g faeces | ||||||||||||
| All studies | 4 | 78.6 (75.6-81.4) | 91.5 | 69.8 (67.9-71.6) | 99.2 | 3.75 (2.08-6.76) | 98.3 | 0.34 (0.27-0.42) | 59.6 | 11.72 (6.41-21.45) | 82.8 | < 0.001 |
| 100% Symptomatic4 | 3 | 80.4 (77.4-83.2) | 89.6 | 67.0 (65.0-68.9) | 99.2 | 2.54 (1.45-4.46) | 98.5 | 0.31 (0.26-0.37) | 23.7 | 8.56 (6.18-11.86) | 49.8 | < 0.001 |
1
Values are expressed as percentages and its 95% confidence interval;
2
Values are expressed as percentages;
3
Values are expressed as absolute numbers and its 95% confidence interval;
4
The studies that comprise the 100% symptomatic subgroup also have CRC prevalence ≥ 2.5%; Pa: Significance of the threshold effect using the Spearman rank correlation (P < 0.01 is considered statistically significant). I2: Inconsistency index; LoD: Limit of detection; LR: Likelihood ratio; OR: Odds ratio; CRC: Colorectal cancer.