Table 7.
Diagnostic accuracy parameters for advanced neoplasia detection based on quantitative faecal immunochemical test for haemoglobin threshold concentration and brand
| Brand | Threshold (µg/g faeces) | Author, year | Sensitivity1 | Specificity1 |
| Mixed cohorts | ||||
| OC-Sensor® | 5 | Ou, 2013[21] | 56.8 (39.5-72.9) | 88.7 (85.7-91.2) |
| OC-Sensor® | 25 | Rozen, 2010[17] | 27.5 (20.3-34.7) | 96.7 (95.8-97.6) |
| OC-Sensor® | 25 | Terhaar sive Droste, 2010[32] | 48.3 (42.6-53.9) | 94.3 (93.2-95.3) |
| OC-Sensor® | 30 | Rozen, 2010[17] | 26.8 (19.9-34.7) | 97.3 (96.5-98.1) |
| OC-Sensor® | 30 | Terhaar sive Droste, 2010[32] | 46.0 (40.4-51.7) | 95.1 (94.1-96.1) |
| OC-Sensor® | 40 | Rozen, 2010[17] | 26.2 (19.1-33.2) | 97.8 (97.0-98.5) |
| OC-Sensor® | 40 | Terhaar sive Droste, 2010[32] | 43.2 (37.6-48.9) | 95.8 (94.8-96.7) |
| HM-JACKarc® | LoD | Auge, 2016[22] | 96.6 (82.8-93.4) | 10.6 (6.9-15.9) |
| HM-JACKarc® | 10 | Auge, 2016[22] | 34.5 (19.9-52.7) | 87.2 (81.6-91.3) |
| HM-JACKarc® | 20 | Auge, 2016[22] | 31.0 (17.3-49.2) | 92.8 (88.0-95.7) |
| HM-JACKarc® | 30 | Auge, 2016[22] | 31.0 (17.3-49.2) | 93.3 (88.7-96.1) |
| HM-JACKarc® | 40 | Auge, 2016[22] | 27.6 (14.7-45.7) | 93.9 (89.4-96.6) |
| FOB Gold® | 10 | Auge, 2018[30] | 45.7 (33.7-58.1) | 84.7 (80.8-88.0) |
| FOB Gold® | 20 | Auge, 2018[30] | 37.1 (26.1-49.6) | 87.9 (84.2-90.8) |
| FOB Gold® | 30 | Auge, 2018[30] | 35.7 (24.6-48.1) | 90.3 (87.0-93.1) |
| FOB Gold® | 40 | Auge, 2018[30] | 32.9 (22.4-45.2) | 91.1 (87.8-93.6) |
| FOB Gold® | 50 | Auge, 2018[30] | 31.4 (20.9-43.6) | 92.3 (89.3-94.7) |
| FOB Gold® | 60 | Auge, 2018[30] | 30.0 (19.9-42.3) | 92.3 (89.2-94.6) |
| 100% symptomatic | ||||
| HM-JACK® | 20 | Parente, 2012[24] | 35.6 (27.9-44.1) | 94.5 (89.7-97.2) |
1
Values are expressed as percentages and its 95% confidence interval.