Table 2.
Similarities and differences between MITRA-FR and COAPT with respect to baseline characteristics of the study populations
| MITRA-FR | COAPT | |
|---|---|---|
| Baseline clinical characteristics | ||
| Age, year | 70 ± 10 | 72 ± 11 |
| NYHA class, % | ||
| I | 0 | 0.2 |
| II | 32.9 | 39.0 |
| III | 58.5 | 52.5 |
| IV | 8.6 | 8.3 |
| Surgical risk | ||
| STS score ≥8% | 42.7% | |
| EuroSCORE II, median and IQR | 6.2 (3.5–11.0) | |
| Baseline echocardiographic characteristics | ||
| MR severity, % | ||
| Moderate (EROA 20-29 mm2) | 52 | 14 |
| Moderate-to-severe (EROA 30-39 mm2) | 32 | 46 |
| Severe (EROA ≥ 40 mm2) | 16 | 41 |
| EROA, mm2 | 31 ± 10 | 41 ± 15 |
| LV end-diastolic volume index, mL/m2 | 135 ± 35 | 101 ± 34 |
| LV ejection fraction, % | 33 ± 7 | 31 ± 9 |
IQR, inter-quartile range; STS, Society of Thoracic Surgery. Other abbreviations as in Table 1.