Figure 2.

Canonical correlation analysis (CCA) assessing the multivariate association between resting‐state connectivity, symptoms, and behavior in children with persistent PCS. (A) A single significant mode of population variation was found between resting‐state connectivity in the seven brain networks (including connectivity between frontoparietal and default mode networks) and behavioral measures and symptoms of persistent PCS. (B) Specific contribution of different brain networks connectivity (left) and behavioral measures (right) to the CCA mode assessed using permutation testing. Significant (p_FWE < 0.05) loading is highlighted by italic, with the relative contribution of each factor indexed by both the text size (larger equates to greater contribution) and color (purple = significant positive load, blue = neutral, red = significant negative load). PCSI= Post Concussion Symptom Inventory (total score).