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Association between rs2013162 and IRF6 expression and AIS. (A) The minor allele C carriers of rs2013162 tend to have lower IRF6 gene expression levels in PBMCs of Chinese individuals. (B) IRF6 was differentially expressed between IS cases and controls according to the data of GSE22255. (C) IRF6 expression seems to be causally associated with AIS (PSMR = 3.64 × 10−4, PHEIDI = 0.11).
