Table 1.
The identified m6A-SNPs for ischemic stroke.
| SNP | CHR | SNP position | MAF | Gene | Mutation Type | P-value≠ | m6A_ID | m6A position | m6A function | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TRAN | EURO | eQTL | DEG | SMR | |||||||||
| AIS | |||||||||||||
| rs2013162 | 1 | 209968684 | 0.3736 | IRF6 | Syn | 1.27E-04 | 6.73E-04 | 6.30E-23 | 6.15E-03 | 3.64E-04 | m6A_ID_132331 | 209968661 | Loss |
| rs13196003 | 6 | 24535999 | 0.0725 | ALDH5A1 | UTR3 | 1.29E-04 | 3.36E-04 | m6A_ID_189376 | 24535978 | Loss | |||
| rs1322257 | 9 | 114480562 | 0.0112 | C9orf84 | Nonsyn | 1.02E-04 | 8.28E-03 | m6A_ID_226979 | 114480545 | Gain | |||
| rs10760214 | 9 | 125002246 | 0.4763 | RBM18 | UTR3 | 7.54E-05 | 6.38E-04 | 1.29E-35 | 2.44E-03 | m6A_ID_227927 | 125002247 | Loss | |
| rs10832778 | 11 | 17394073 | 0.3885 | NCR3LG1 | UTR3 | 4.25E-05 | 3.97E-04 | 1.18E-17 | m6A_ID_244519 | 17394071 | Gain | ||
| rs5213 | 11 | 17408404 | 0.3615 | KCNJ11 | UTR3 | 2.46E-05 | 4.49E-04 | 7.57E-13 | 7.21E-04 | m6A_ID_27449 | 17408423 | Loss | |
| rs7398833 | 12 | 111786892 | 0.2509 | CUX2 | UTR3 | 1.78E-05 | 2.46E-05 | 1.51E-02 | m6A_ID_265695 | 111786917 | Gain | ||
| rs11076256 | 16 | 58752466 | 0.0818 | GOT2 | Nonsyn | 1.29E-04 | 3.46E-03 | m6A_ID_43360 | 58752472 | Loss | |||
| rs11559309 | 17 | 1556911 | 0.0374 | PRPF8 | Syn | 6.18E-06 | 7.83E-06 | m6A_ID_301320 | 1556907 | Gain | |||
| LAS | |||||||||||||
| rs11121484 | 1 | 9784423 | 0.0769 | PIK3CD | Syn | 1.40E-04 | 1.18E-02 | 4.20E-02 | m6A_ID_112617 | 9784425 | Gain | ||
| rs116577362 | 5 | 140242897 | 0.0215 | PCDHA | Nonsyn | 1.04E-04 | 1.04E-04 | m6A_ID_184329 | 140242899 | Loss | |||
| rs174535 | 11 | 61551356 | 0.3392 | MYRF | Nonsyn | 1.31E-04 | 6.05E-05 | m6A_ID_247771 | 61551331 | Gain | |||
| rs17875563 | 15 | 81604293 | 0.2405 | IL16 | UTR3 | 1.67E-04 | 1.83E-03 | 9.52E-09 | 3.97E-02 | m6A_ID_287576 | 81604291 | Gain | |
| CES | |||||||||||||
| rs2273235 | 5 | 149907533 | 0.4821 | NDST1 | Syn | 3.99E-04 | 1.04E-03 | 3.23E-07 | 2.65E-02 | 8.47E-03 | m6A_ID_185695 | 149907528 | Loss |
| SVS | |||||||||||||
| rs1887812 | 1 | 92414993 | 0.2074 | BRDT | UTR5 | 4.05E-04 | 8.51E-04 | m6A_ID_121270 | 92414991 | Loss | |||
AIS, Any ischemic stroke; CES, Cardioembolic stroke; CHR, Chromosome; DEG, Differential expression gene; eQTL, Expression quantitative trait; LAS, Large artery stroke; MAF, Minor allele frequency (in Europeans); Nonsyn, Nonsynonymous; SMR, Summary data based Mendelian randomization; SNP, Single nucleotide polymorphism; SVS, Small vessel stroke; Syn, Synonymous; UTR, Untranslated region. †Assembly: GRCh37.p13. ≠TRAN: stroke association P values based-on trans ethnic data; EURO, Stroke association P-values based-on European-only data.