Table 1.

Reactive centre loop sequences for human serpins*

	Serpin	P15	P14	P13	P12	P11	P10	P9	P8	P7	P6	P5	P4	P3	P2	P1	P1’	P2’	P3’	P4’
Inhibitory	A1	G	T	E	A	A	G	A	M	F	L	E	A	I	P	M	S	I	P	P
	A2	G	T	E	A	T	G	A	P	H	L	E	E	K	A	W	S	K	Y	Q
	A3	G	T	E	A	S	A	A	T	A	V	K	I	T	L	L	S	A	L	V
	A4	G	T	E	A	A	A	A	T	T	F	A	I	K	F	F	S	A	Q	T
	A5	G	T	R	A	A	A	A	T	G	T	I	F	T	F	R	S	A	R	L
	A9	G	T	E	A	T	A	A	T	T	T	K	F	I	V	R	S	K	D	G
	A10	G	T	E	A	V	A	G	I	L	S	E	I	T	A	Y	S	M	P	P
	B1	G	T	E	A	A	A	A	T	A	G	I	A	T	F	C	M	L	M	P
	B2	G	T	E	A	A	A	G	T	G	G	V	M	T	G	R	T	G	H	G
	B3	G	A	E	A	A	A	A	T	A	V	V	G	F	G	S	S	P	A	S
	B4	G	V	E	A	A	A	A	T	A	V	V	V	V	E	L	S	S	P	S
	B6	G	T	E	A	A	A	A	T	A	A	I	M	M	M	R	C	A	R	F
	B7	G	T	E	A	T	A	A	T	G	S	N	I	V	E	K	Q	L	P	Q
	B8	G	T	E	A	A	A	A	T	A	V	V	R	N	S	R	C	S	R	M
	B9	G	T	E	A	A	A	A	S	S	C	F	V	V	A	E	C	C	M	E
	B10	G	T	E	A	A	A	G	S	G	S	E	I	D	I	R	I	R	V	P
	B11	G	T	E	A	A	A	A	T	G	D	S	I	A	V	K	S	L	P	M
	B12	G	T	Q	A	A	A	A	T	G	A	V	V	S	E	R	S	L	R	S
	B13	G	T	E	A	A	A	A	T	G	I	G	F	T	V	T	S	A	P	G
	C1	G	S	E	A	A	A	S	T	A	V	V	I	A	G	R	S	L	N	P
	D1	G	T	Q	A	T	T	V	T	T	V	G	F	M	P	L	S	T	Q	V
	E1	G	T	V	A	S	S	S	T	A	V	I	V	S	A	R	M	A	P	E
	E2	G	T	K	A	S	A	A	T	T	A	I	L	I	A	R	S	S	P	P
	F2	G	V	E	A	A	A	A	T	S		I	A	M	S	R	M	S	L	S
	G1	G	V	E	A	A	A	A	S	A		I	S	V	A	R	T	L	L	V
	I1	G	S	E	A	A	A	V	S	G	M	I	A	I	S	R	M	A	V	L
	I2	G	S	E	A	A	T	S	T	G	I	H	I	P	V	I	M	S	L	A
Non‐inhibitory	A6	G	V	D	T	A	G	S	T	G	V	T	L	N	L	T	S	K	P	I
	A7	G	T	E	A	A	A	V	P	E	V	E	L	S	D	Q	P	E	N	T
	A8	G	R	E	P	T	E	S	T	Q	Q	L	N	K	P	E	V	L	E	V
	B5	G	G	D	S	I	E	V	P	G	A	R	I	L	Q	H	K	D	E	L
	F1	G	A	G	T	T	P	S	P	G	L	Q	P	A	H	L	T	F	P	L
	H1	G	N	P	F	D	Q	D	I	Y	G	R	E	E	L	R	S	P	K	L
	H2	G	N	P	F	D	Q	D	I	Y	G	R	E	E	L	R	S	P	K	L

*Based on Chou–Fasman helix and sheet propensities, the RCL residues were dichotomized to give the top 10 β‐sheet prone amino acids (A, F, H, I, L, M, T, V, W and Y) and shaded in the table. A gap has been introduced at P6 for F2 and G1 to maintain the alignment of residues.