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. 2019 May 22;7:132. doi: 10.1186/s40425-019-0601-5

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Listeria based Immunotherapy with concomitant CD8+ T cell depletion. Mice implanted with KPC PDAC cells on day 0 underwent treatment with Lm-ANXA2 as described (n = 10–12 mice per group). CD8+ depletion was started on day 2 via anti-CD8a antibody (10 mg/kg IP; 2.43, BioXcell) until day 30. Kaplan-Meier curves reveal survival in PDAC bearing mice treated with Lm-ANXA2 and CD8+ T cell depletion is significantly shorter than that of mice treated with Lm-ANXA2 without CD8+ T cell depletion (p = 0.027)