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. 2019 May 22;25:22. doi: 10.1186/s10020-019-0091-4

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Effect of EA stimulus on the expression of NLRP3 inflammasome. a Representative western immunoblotting analysis of NLRP3, Caspase-1 and IL-1β (n = 4). EA stimulus significantly decreased the levels of NLRP3, procaspase-1, Cl.Caspase-1, GSDMD, GSDMD-N, proIL-1β and mature IL-1β when compared with MCAO group. **P < 0.01, ***P < 0.001 vs. Sham group, ^##P < 0.01, ^###P < 0.001 vs. MCAO group. (b, c) Immunofluorescent staining of NLRP3, Caspase-1, neuronal nuclei (NeuN), and nuclear marker DAPI. EA stimulus decreased the levels of NLRP3 positive neurons and Caspase-1 positive neurons when compared with MCAO group. Scale bar = 30 μm