Table 2.

Expression of miRNAs having protective and pathogenic association10 in progressive MS brain

miRs #	miRNAs	WML/NAWM	P‐value
Protective
1	hsa‐miR‐199a‐3p	2.71	0.0088
2	hsa‐miR‐143	2.26	0.0080
3	hsa‐miR‐199a‐5p	1.81	0.0084
4	hsa‐miR‐30d	1.53	0.0240
5	hsa‐miR‐362‐5p	1.24	0.0227
6	hsa‐miR‐574‐3p	−0.49	0.0080
7	hsa‐miR‐23b	−0.54	0.0280
8	hsa‐miR‐18a	−1.25	0.0070
9	hsa‐miR‐27b	−1.51	0.0007
10	hsa‐miR‐181c	−1.53	0.0193
11	hsa‐miR‐338‐3p	−2.97	0.0080
12	hsa‐miR‐219‐5p	−14.67	0.0142
Pathogenic
1	hsa‐miR‐320b	2.80	0.0040
2	hsa‐miR‐320a	2.58	0.0162
3	hsa‐miR‐22	2.49	0.0120
4	hsa‐miR‐188‐5p	2.05	0.0319
5	hsa‐miR‐145	1.63	0.0047
6	hsa‐miR‐30d	1.53	0.0240
7	hsa‐miR‐222	1.41	0.0336
8	hsa‐miR‐628‐3p	−0.75	0.0080
9	hsa‐miR‐27b*	−0.87	0.0026
10	hsa‐miR‐15a	−0.96	0.0193
11	hsa‐miR‐7	−4.10	0.0004

miRNAs in bold letters were also validated in independent cohorts by qPCR. miR‐145 and miR‐181c was additionally validated using in situ hybridization.