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. 2019 May 21;19:140. doi: 10.1186/s12935-019-0838-6

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — HOXA11-AS increases PDK1 expression by inhibiting miR-518a-3p. a Bioinformatics analysis showed the predicted binding site between PDK1 and miR-518a-3p. b Luciferase activity was detected in HEK293T cells co-transfected with miR-518a-3p mimics and luciferase reporters containing PDK1 or mutant form. c The expression of PDK1 in OSCC tissues or adjacent normal tissues was measured by immunohistochemistry (IHC) assay. d, e The expression of PDK1 mRNA and protein in indicated groups were detected in SCC-25 cells by using qRT-PCR and western blotting. f, g The expression of PDK1 protein in indicated groups were detected in SCC-25 cells by using qRT-PCR and western blotting. h Positive correlation between HOXA11-AS and PDK1 expression in OSCC tissues. i Negative correlation between PDK1 and miR-518a-3p in OSCC tissues. (^#P < 0.05, **P < 0.01)