Table 3.
Associations between SNPs and DKD susceptibility in type 2 diabetic patients.
| SNP | Major/minor allele | Major allele frequency | P allele | OR (95% CI) | Genotype count | P genotype | OR (95% CI) | ||
|---|---|---|---|---|---|---|---|---|---|
| DKD | Non-DKD | DKD AA/Aa/aa† |
Non-DKD AA/Aa/aa† |
||||||
| rs2071699 | C/T | 0.717 | 0.707 | 0.5845 | 1.049 (0.884, 1.245) | 290/239/42 | 357/306/58 | 0.5511 | 1.062 (0.871, 1.296) |
| rs499765 | G/C | 0.585 | 0.584 | 0.9306 | 1.007 (0.860, 1.179) | 201/263/104 | 244/349/124 | 0.7234 | 0.968 (0.811, 1.157) |
| rs838136 | A/G | 0.592 | 0.618 | 0.1818 | 0.897 (0.766, 1.052) | 199/282/93 | 282/320/113 | 0.4146 | 0.928 (0.776, 1.110) |
†AA = major allele homozygous; Aa = heterozygous; aa = minor allele homozygous. Pallele refers to the P value for the comparison of the allele frequency between the DKD group and the control group. Pgenotype refers to the P value for the comparison of genotype distribution between the DKD group and the control group, which was adjusted for age, gender, BMI, duration of diabetes, systolic blood pressure, diastolic blood pressure, and HbA1c. The ORs with 95% CIs shown are for the major alleles of the SNPs.