Table 6.
Associations between the SNPs and AER (mg/24 h) in the study subjects.
| SNP | Major/minor allele | AA† | Aa† | aa† | β (SE)‡ | P value | |
|---|---|---|---|---|---|---|---|
| DKD group | rs2071699 | C/T | 100.6 (48.3, 318.7) | 82.2 (45.1, 283.4) | 78.5 (37.1, 262.0) | 0.030 (0.039) | 0.4389 |
| rs499765 | G/C | 90.0 (52.4, 334.3) | 89.1 (42.7, 289.0) | 89.8 (44.6, 267.5) | 0.030 (0.034) | 0.3782 | |
| rs838136 | A/G | 77.3 (43.0, 282.3) | 103.2 (50.1, 292.6) | 90.1 (46.1, 227.4) | -0.028 (0.035) | 0.4327 | |
|
| |||||||
| Non-DKD group | rs2071699 | C/T | 9.5 (6.5, 14.7) | 8.7 (6.0, 13.8) | 9.4 (6.8, 13.6) | 0.014 (0.014) | 0.3311 |
| rs499765 | G/C | 9.7 (6.1, 14.1) | 9.0 (6.4, 14.7) | 8.5 (6.5, 14.1) | 0.0006 (0.013) | 0.9632 | |
| rs838136 | A/G | 8.9 (6.2, 13.8) | 8.8 (6.2, 14.9) | 10.0 (6.9, 14.6) | -0.007 (0.013) | 0.5667 | |
Data are shown as geometric means (SE). P values were adjusted for age, gender, BMI, duration of diabetes, systolic blood pressure, diastolic blood pressure, and HbA1c. †AA = major allele homozygous; Aa = heterozygous; aa = minor allele homozygous. ‡β (SE) was calculated for log10eGFR and refers to major alleles. AER: 24-hour urinary albumin excretion rate.