Table 2.

Main characteristics of included studies about PD-1 in this meta-analysis

Author	Year	Origin	Range of year	Categories	No. of patients	Cut off value for PD-1 positive	No. of positive	Detected area	Endpoints	Detection method	Hazard ratio	Calculation of HRs	Quality score
Cao et al.	2018	China	NA	Primary	108	H-score > 0	41	TIL	OS	FFPE, IHC	Report	Multivariate	7
Hsu et al.	2010	China	2003–2004	Primary	46	> Median expression rate: 27.8% (intratumoral CD8), > median expression rate: 14.5% (intratumoral CD4)	23, 23	Intratumoral CD8, intratumoral CD4	OS	FFPE, IHC	Report	Multivariate	7
Lu et al.	2018	China	2007–2012	Primary	197	PD-1 staining intensity 2 in > 5% of TILs	96	TIL	OS	FFPE, IHC	K–M curve	Univariate	7
Tang et al.	2017	China	NA	NA	96	NA	36	TIL	OS	FFPE, IHC	K–M curve	Univariate	6
Zhou et al.	2017	China	2001–2013	Recurrence	132	NA	50	TIL	OS	FFPE, IHC	Report	Univariate	9
Zhou et al. [2]	2017	China	2010–2012	Primary	99	PD-1 staining intensity 2 in > 5% of TILs	44	TIL	OS	FFPE, IHC	K–M curve	Univariate	9

FFPE: Formalin-Fixed and Paraffin-Embedded; HRs: hazard ratios; IHC: immunohistochemistry; K–M curve: Kaplan–Meier curve; NA: not available; No: number; OS: overall survival; TIL: tumor infiltrating lymphocytes