Table 1.
Associations of NHL subgroups with HBsAg: univariate & multivariate logistic regression analyses
| Group | All | HBsAg+ | Univariable | Multivariable | ||||
|---|---|---|---|---|---|---|---|---|
| N | No. % | OR | 95% CI | *P | AOR | 95% CI | P | |
| Control | 7004 | 614 (8.8) | 1 | Reference | 1 | Reference | ||
| NHL | 3502 | 523 (14.9) | 1.83 | 1.61–2.07 | < 0.001 | 1.83 | 1.61–2.07 | < 0.001 |
| B-NHL | 2535 | 432 (17.0) | 2.14 | 1.87–2.44 | < 0.001 | 2.14 | 1.88–2.45 | < 0.001 |
| DLBCL | 1224 | 231 (18.9) | 2.42 | 2.05–2.86 | < 0.001 | 2.45 | 2.07–2.89 | < 0.001 |
| BL | 90 | 11 (12.2) | 1.45 | 0.77–2.74 | 0.25 | 1.69 | 0.89–3.22 | 0.11 |
| FL | 253 | 42 (16.6) | 2.07 | 1.47–2.91 | < 0.001 | 2.13 | 1.52–3.01 | < 0.001 |
| MCL | 105 | 14 (13.3) | 1.60 | 0.91–2.83 | 0.11 | 1.53 | 0.86–2.70 | 0.15 |
| MALT | 314 | 47 (15.0) | 1.83 | 1.33–2.53 | < 0.001 | 1.89 | 1.37–2.60 | < 0.001 |
| LPL | 30 | 2 (0.7) | 0.74 | 0.18–3.13 | 0.74 | 0.74 | 0.18–3.13 | 0.69 |
| PBLL | 37 | 5 (13.5) | 1.63 | 0.63–4.19 | 0.31 | 3.79 | 1.38–10.38 | 0.01 |
| CLL/SLL | 341 | 58 (17.0) | 2.13 | 1.59–2.86 | < 0.001 | 2.12 | 1.58–2.85 | < 0.001 |
| other B-NHL | 141 | 22 (15.6) | 1.92 | 1.21–3.06 | 0.01 | 1.99 | 1.25–3.16 | 0.004 |
| T-NHL | 967 | 91 (9.4) | 1.08 | 0.86–1.36 | 0.51 | 1.11 | 0.88–1.40 | 0.40 |
| NK/T | 436 | 34 (7.8) | 0.88 | 0.61–1.26 | 0.49 | 0.89 | 0.62–1.28 | 0.53 |
| PTCL-unclassified | 161 | 17 (10.6) | 1.23 | 0.74–2.05 | 0.43 | 1.24 | 0.74–2.06 | 0.41 |
| ALCL | 73 | 10 (13.7) | 1.65 | 0.84–3.24 | 0.14 | 2.07 | 1.05–4.11 | 0.04 |
| PTLL | 119 | 8 (6.7) | 0.75 | 0.36–1.54 | 0.44 | 0.95 | 0.45–1.96 | 0.88 |
| AITL | 122 | 18 (14.8) | 1.80 | 1.09–2.99 | 0.02 | 1.84 | 1.10–3.06 | 0.02 |
| other T-NHL | 56 | 4 (7.1) | 0.80 | 0.29–2.22 | 0.67 | 0.80 | 0.29–2.23 | 0.67 |
Abbreviations: HBV = hepatitis B virus, HBsAg = hepatitis B surface antigen, CI = confidence interval, DLBCL = diffuse large B-cell lymphoma, BL = Burkitt’s lymphoma, FL = follicular lymphoma, MCL = mantle cell lymphoma, MALT = marginal zone lymphoma, LPL = lymphoplasmacytic lymphoma, PBLL = precursor B lymphoblastic lymphoma, CLL/SLL = small lymphocytic lymphoma/chronic lymphocytic leukaemia, NK/T = NK/T-cell lymphoma, PTCL = peripheral T-cell lymphoma, ALCL = anaplastic large cell lymphoma, PTLL = precursor T lymphoblastic lymphoma, AITL = angioimmunoblastic T-cell lymphoma, OR = odds ratio, AOR = adjusted odds ratio. The results were adjusted by age (as a continuous variable), sex and year of diagnosis. * Statistically significant at the 0.05 alpha level