Table 3.
Clinical influenza vaccine study group comparisons using data from mPLEX-Flu, HAI, and MN assays.
| Day | Group comparison | mPLEX-Flu | HAI | MN | |||
|---|---|---|---|---|---|---|---|
| Δ (SE) | p value | Δ (SE) | p value | Δ (SE) | p value | ||
| 0 | Multiple vs. primed | 0.78 (0.21) | 0.0002∗∗ | 0.25 (0.29) | 0.4003 | 0.25 (0.34) | 0.4658 |
| Multiple vs. unprimed | 1.28 (0.23) | <0.0001∗∗ | 0.27 (0.31) | 0.3912 | 0.54 (0.36) | 0.1362 | |
| Primed vs. unprimed | 0.50 (0.19) | 0.0109 | 0.02 (0.23) | 0.9298 | 0.29 (0.26) | 0.2698 | |
|
| |||||||
| 7 | Multiple vs. primed | 0.29 (0.21) | 0.1831 | −0.41 (0.30) | 0.1648 | −0.47 (0.34) | 0.1736 |
| Multiple vs. unprimed | 1.32 (0.25) | <0.0001∗∗ | 0.96 (0.31) | 0.0024∗ | 1.72 (0.36) | <0.0001∗∗ | |
| Primed vs. unprimed | 1.04 (0.21) | <0.0001∗∗ | 1.37 (0.23) | <0.0001∗∗ | 2.19 (0.26) | <0.0001∗∗ | |
|
| |||||||
| 14 | Multiple vs. primed | 0.08 (0.21) | 0.7010 | −0.40 (0.29) | 0.1807 | 0.13 (0.34) | 0.7005 |
| Multiple vs. unprimed | 1.25 (0.25) | <0.0001∗∗ | 1.56 (0.31) | <0.0001∗∗ | 2.97 (0.36) | <0.0001∗∗ | |
| Primed vs. unprimed | 1.17 (0.21) | <0.0001∗∗ | 1.95 (0.23) | <0.0001∗∗ | 2.84 (0.26) | <0.0001∗∗ | |
|
| |||||||
| 28 | Multiple vs. primed | 0.44 (0.22) | 0.0483 | −0.17 (0.29) | 0.5571 | −0.15 (0.34) | 0.6559 |
| Multiple vs. unprimed | 1.32 (0.25) | <0.0001∗∗ | 1.65 (0.31) | <0.0001∗∗ | 2.41 (0.36) | <0.0001∗∗ | |
| Primed vs. unprimed | 0.88 (0.21) | <0.0001∗∗ | 1.83 (0.23) | <0.0001∗∗ | 2.56 (0.27) | <0.0001∗∗ | |
|
| |||||||
| 56 | Multiple vs. primed | 0.31 (0.21) | 0.1388 | −0.08 (0.29) | 0.7819 | −0.16 (0.34) | 0.6306 |
| Multiple vs. unprimed | 1.16 (0.24) | <0.0001∗∗ | 1.14 (0.31) | 0.0003∗∗ | 1.35 (0.36) | 0.0003∗∗ | |
| Primed vs. unprimed | 0.85 (0.21) | <0.0001∗∗ | 1.22 (0.23) | <0.0001∗∗ | 1.51 (0.27) | <0.0001∗∗ | |
|
| |||||||
| 180 | Multiple vs. primed | 0.72 (0.20) | 0.0006∗∗ | 0.10 (0.29) | 0.7293 | 0.21 (0.34) | 0.5351 |
| Multiple vs. unprimed | 1.46 (0.24) | <0.0001∗∗ | 0.89 (0.32) | 0.0050∗ | 1.10 (0.36) | 0.0027∗ | |
| Primed vs. unprimed | 0.75 (0.21) | 0.0003∗∗ | 0.79 (0.23) | 0.0008∗∗ | 0.89 (0.27) | 0.0010∗∗ | |
|
| |||||||
| Overall mean | Multiple vs. primed | 0.56 (0.18) | 0.0021∗ | 0.04 (0.23) | 0.8501 | 0.13 (0.28) | 0.6547 |
| Multiple vs. unprimed | 1.31 (0.20) | <0.0001∗∗ | 0.88 (0.24) | 0.0003∗∗ | 1.30 (0.29) | <0.0001∗∗ | |
| Primed vs. unprimed | 0.75 (0.17) | <0.0001∗∗ | 0.84 (0.17) | <0.0001∗∗ | 1.17 (0.20) | <0.0001∗∗ | |
Note. Linear mixed models were used to fit the data from the mPLEX-Flu, HAI, and MN assays with adjustment for dose, age at enrollment, gender, ethnicity, and batches. Pairwise comparisons were used to compare overall group differences and group differences at each day for the three vaccine groups (Δ means estimated differences between groups, SE means standard errors associated with Δ, ∗∗ p ≤ 0.001, and ∗ p ≤ 0.01).