Table 2.

Predicted miRNAs and their potential targets in autophagy of OA chondrocytes.

microRNAs	Differential expression in OA cartilage, References	Potential related targets or genes	Mechanisms or functions	Research diseases, cells or models	References
miR-140-5p	[66]	ULK1	Autophagy	Human HEK 293T cells	[81]
miR-93	[82]	ULK1	Autophagy	Mouse embryonic fibroblasts (MEFs), Chinese hamster ovary cells (CHO)	[83]
miR-26a-5p	[84, 85]	ULK1	Autophagy	Primary cardiac fibroblasts from neonatal rats	[86]
miR-25	[87]	ULK1	Autophagy	Human breast cancer cells (MCF-7), normal human mammary epithelial cell (MCF-10A)	[88]
miR-558	[12, 89]	lncRNA MALAT1, ULK1	Autophagy and apoptosis	Rat myocardial cells, H9C2	[90]
miR-210	[91]	ATG7	Autophagy	Human lumbar degenerated NP cells	[92]
miR-29a	[1, 91]	TFEB, ATG9A	Autophagy	Human pancreatic epithelial cells, HPNE and HPDE	[93]
miR-23b-3p	[87]	ATG12	Autophagy	Traumatic brain injury, SD rats	[94]
miR-125b-5p	[85, 95]	UVRAG	Autophagy	Systemic lupus erythematosus, human PBMCs	[96]
miR-218-5p	[97]	PIK3C2A, PI3K/AKT/mTOR	Matrix synthesis, proliferation and apoptosis	Human osteoarthritic chondrocytes, SW1353 and C28/I2 cells	[97]
miR-634	[98]	PIK3R1, PI3K/AKT/mTOR/S6	Matrix synthesis and survival	Human osteoarthritic chondrocytes, HEK293 cells	[98]
miR-145	[95, 99, 100]	PI3K/AKT/mTOR	Autophagy	Human umbilical cord-derived mesenchymal stem cells, HK-2 cell	[101]
miR-181b	[102]	PTEN/Akt/mTOR	Autophagy	Parkinson's disease, PC12 cells	[103]
miR-302b	[104]	Smad3, Notch2, mTOR pathway	Inflammation suppression	Human chondrocytes, C-28/I2 cells	[104]
mir-148a-3p	[85, 95]	RAB12, mTOR1	Autophagy	Gastric cancer, BGC823/CDDP and SGC7901/CDDP cells	[105]
miR-99a-5p	[106]	mTOR	Autophagy and apoptosis	Human immortalized uroepithelial cells (SV-Huc1), bladder cancer cells 5637 (HTB-9) and T24 (HTB-4)	[107]
miR-222-3p	[108]	ATG12/p27-mTOR	Autophagy	Human MM cells, MM.1S, MM.1R, RPMI-8226, U266, NCIH929, and ARH-77	[109]
miR-199a-3p	[110, 111]	IGF-1, mTOR	Autophagy	Osteocyte-like MLO-Y4 cells	[112]
miR-27b-3p	[85, 113]	PTEN-induced putative kinase 1 (PINK1)	Autophagy	Human cervical HeLa, dopaminergic-like M17 cells	[114]
miR-24	[115]	SIRT1, deacetylated LC3	Autophagy	Uterine sarcoma	[116]
miR-138-5p	[117]	SIRT1	Autophagy	Human neuroblastoma cells (SH-SY5Y)	[118]
miR-34a	[28]	ATG4B	Autophagy	Tubular epithelial cells	[119]
miR-34a	[28]	ATG9A	Autophagy	SD rat cardiomyocytes	[120]
miR-34a	[28]	circRNA.2837	Neuronal autophagy	SD rat spinal neurons	[121]
miR-22-3p	[85, 91]	Metadherin (MTDH)	Autophagy	Human osteosarcoma cells (MG-63)	[122]
miR-377	[91, 100]	Rapamycin	Autophagy	Murine macrophage RAW264.7 cells	[123]
miR-103	[91, 100]	SOX2	Autophagy and apoptosis	LPS-injured PC12 cells, SD rats	[124]
miR-193b	[110]	Stathmin 1	Autophagy and non-apoptotic cell death	Human oesophageal cancer cells, OE19, OE21 and OE33	[125]
miR-16-5p	[87]	Guanine nucleotide-binding α-subunit12 (Gα12)	Autophagy	Hepatic stellate cells, HSCs	[126]
miR-320	[95, 127]	HIF-1α	Autophagy	Human RB cells (WERI-RB1)	[128]
miR-195	[129]	GABARAPL1	Autophagy, proliferation, migration and angiogenesis	Human endothelial progenitor cells (hEPCs)	[130]