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. 2019 May 15;10:465. doi: 10.3389/fgene.2019.00465

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Copyright © 2019 Schönauer, Seidel, Grohmann, Lindner, Bergmann and Halbritter.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Influence of CFH on complement activation. CFH inhibits the conversion of C3 to C3b by accelerating the decay of C3 convertases and enhancing the inactivation of C3b and prevents conversion of C5 to C5b by accelerating the decay of C5 convertases. CFB: complement factor B; CFD: complement factor D; MAC: membrane attack complex.