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. 2019 May 15;10:465. doi: 10.3389/fgene.2019.00465

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Copyright © 2019 Schönauer, Seidel, Grohmann, Lindner, Bergmann and Halbritter.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Statistical evaluation of aHUS-associated CFH variants according to HGMD 2018.4. (A) Frequency of aHUS-associated variant subtypes. (B) Mapping of total (light colors) and aHUS-associated (dark colors) missense/non-sense variants onto distinct SCR domains of CFH. SCR 18 is highlighted in red. SCR, short consensus repeat.