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. 2019 May 14;13:157. doi: 10.3389/fncel.2019.00157

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Copyright © 2019 Bonsack and Sukumari-Ramesh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Galectin-3 and inflammatory response (A) RAW 246.7 cells were treated with either control siRNA or Galectin-3 siRNA as detailed in methods and the genetic knockdown of Galectin-3 was verified using (A) western blotting followed by (B) densitometry analysis. ^∗∗∗p < 0.001 vs. control siRNA. (C) Galectin-3 knockdown didn’t modulate LPS-induced release of IL-6 (D) whereas significantly unregulated hemin–induced release of IL-6 from RAW 246.7 cells in comparison to control (n = 3 per group). ^∗∗p < 0.01 vs. hemin.