Table 1.
Summary of MEMRI protocols used for the detection of neuroarchitecture in the visual system in terms of species, delivery route, Mn2+ dose, magnetic field strength and anatomical structures enhanced and studied.
| Species | Delivery route | Mn2+ dose | Field strength | Anatomical structures of interest | Citation | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Retina | ON | SC | LGN | VC | Others | |||||
| FVB mice | Intravenous | 88 mg/kg; 120 mM; 250 μL/h | 11.7 T | ✓ | Lee et al., 2005 | |||||
| C57BL/6J mice | Subcutaneous osmotic pump | 180 mg/kg; 0.25–1.0 μL/h | 7 T | ✓ | Mok et al., 2012 | |||||
| RCS rats, Sprague-Dawley rats | Intravitreal | 5 μL; 30 mM | 4.7 T | ✓ | Nair et al., 2011 | |||||
| Sprague-Dawley rats | Intrathecal | 50 μL; 25 mM | 4.7 T | ✓ | Liu et al., 2004 | |||||
| Intravenous | 2.0 mL; 64 mM; 1.8 mL/h | 11.7 T | ✓ | ✓ | Aoki et al., 2004 | |||||
| Subcutaneous | 75, 150, 300 mg/kg; 25, 50, 100 mM | 2 T | ✓ | Shazeeb and Sotak, 2012 | ||||||
| Intraperitoneal | 45 mg/kg; 100 mM | 7 T | ✓ | ✓ | Chan et al., 2017 | |||||
| Old-World fruit bats | Intraperitoneal | 3 mL/kg | 7 T | ✓ | Liu et al., 2015 | |||||
| Common marmosets | Intravenous | 40 mM; 1.25 mL/h | 7 T | ✓ | Bock et al., 2009 | |||||
If a study examined dose-dependent effects, the reported optimal dose was chosen (ON, optic nerve; SC, superior colliculus; LGN, lateral geniculate nucleus; VC, visual cortex).