Table 2.
Studies that correlated DTI metrics on the CST in the acute phase (days 2–7 post-stroke) with motor outcomes assessed at least 4 weeks after stroke.
| Study | Lesion characteristics | Demographics | Details of acquisition |
Technique/ software/ metrics |
Mentioned lesion mask | CST | Time of evaluation (months after stroke) | Reported rehabilitation | Outcome | Did CST DTI metrics correlate with outcomes? | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Type | Time period after stroke for DTI acquisition (days) | Lesion site or arterial territory if IS | n | Gender M/F | Age range | Mean age (SD) | MRI field (T) | Directions/b0 | b value (s/mm2) | Ipsilateral | Contralateral | ||||||||
| IS | HS | ||||||||||||||||||
| Yoshioka et al. (101) |  |
√ | 2–5 | Thalamus, putamen | 17 | 12/5 | 49–74 | 61.8 (NS) | 1.5 | 13/NS | 1,000 | Tractography (NS) dTV II and VOLUME ONE ROI: CP to precentral gyrus FA, rFA |
|
√ | √ | 3 | |
MMT | rFA: yes r = 0.55 p < 0.05 |
| Puig et al. (93) | √ | |
3 | Middle cerebral artery | 60 | 38/22 | 45–85 | 68.2 (13.6) | 1.5 | 15/NS | 1,000 | ROI: rostral pons DTIWeb 2.0 FA, rFA |
|
√ | √ | 1 | |
NIHSSm | No |
| Kuzu et al. (102) | |
√ | 3 | Thalamus, putamen | 23 | 12/11 | 44–85 | 65 (13) | 3.0 | 6/1 | 800 | ROI: CP Functoll (GE) FA |
|
√ | √ | 3 | |
NIHSSm (3 m) | FA: yes (CC not given; p = 0.006) |
| Wang et al. (95) | |
√ | 3 | Thalamus, putamen | 27 | 14/13 | 42–77 | 60.2 (10.5) | 1.5 | 15/NS | 1,000 | ROI: CP SPM99 rFA, rMD |
|
√ | √ | 6 | |
PG (6 m) mRS (17 m) FIM (17 m) |
rFA: yes PG, r = −0.642 mRS, r = −0.549 FIM, r = 0.532 |
| Groisser et al. (94) | √ | |
3–7 | Middle cerebral artery | 10 | 5/5 | 19–67 | 53 (13) | 3.0 | 60/10 | 700 | Tractography (NS) ROI: 10 voxels with highest density Trackvis r (FA, AD, RD) |
√ | √ | √ | 6 | |
Hand grip MI NHPT |
rAD: yes Hand grip, rs = 0.85 MI, rs = 0.97 NHPT: no rFA and rRD: no |
| Doughty et al. (103) | √ | |
2 | Cerebral hemisphere | 58 | 24/34 | NS | 61.3 (14.2) | 1.5 | 30/1 | 1,000 | ROI: CP and N5S SPM and MRIcro, aFA |
√ | √ | √ | 3 | √ | FMA | aFA, N5S: yes aFA, CP: no |
NS, not specified; IS, ischemic stroke; HS, hemorrhagic stroke; CST, corticospinal tract; r, ratio between ipisilesional/contralesional; FA, fractional anisotropy; aFA, asymmetry between (contralesional-ipsilesional)/(contralesional+ipsilesional) fractional anisotropy; MD, mean diffusivity; AD, axial diffusivity; RD, radial diffusivity; CC, correlation coefficient; ROI, region of interest; CP, cerebra peduncle; PLIC, Posterior Limb of the internal capsules; N5S, nearest 5 slices; aFA, FA asymmetry; PG, Paresis Grading; MMT, Manual Muscle Test; NIHSSm, National Institutes of Health Stroke Scale; mRS, Modified Rankin Scale; NHPT, Nine Hole Peg Test; FIM, Functional Independence Measures; FMA, Fugl-Meyer Motor Assessment; MMT, Manual Muscle Testing.