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Chronic liver disease results in increased LEC proliferation. (A) Frequency of LECs (left) and PECs (right) in each stage of cell cycle based on gene expression from single cell sequencing data. (B) Representative flow cytometric profiles of LECs from non-diseased (left and red) or diseased (right and blue). (C) Quantification of (B). (D) Hierarchical clustering of differentially expressed genes from LECs sorted from non-diseased (ND), NASH, or HCV explanted livers.
