Table 2.
The relationship between kisspeptin and metabolic profiles in PCOS women.
| Reference | Sample size | Kisspeptin and LH | Insulin resistance and kisspeptin | BMI and kisspeptin | Other metabolic profile |
|---|---|---|---|---|---|
| Emekci Ozay, et al. (26) | 250 | (+) | HOMA-IR, blood glucose, insulin, (NA) | NA | Leptin(+) |
| Albalawi et al. (25) | 28 | (+) | \ | NA | \ |
| Chen et al. (22) | 19 | (+) | 2 h glucose(+), HOMA-IR, fasting glucose, fasting insulin, 2 h insulin (–) | NA | T levels(+) |
| Daghestani (27) | 44 | NA | Insulin, fasting glucose(–) | NA | HDL(+); TG(–) |
| Gorkem et al. (23) | 60 | NA | \ | NA | DHEAS, TT(+); FSH(–) |
| Jeon et al. (28) | 33 | NA | HOMA-IR, glucose, insulin, glucose/insulin ratio (–) | NA | RBP4(+) |
| Nyagolova et al. (29) | 87 | NA | BMI <25: HOMA-IR, insulin(NA); Fasting glucose(–); BMI>25: HOMA-IR, fasting insulin(+); | \ | BMI>25: age, T, SHBG, and FAI(+) |
| Panidis et al. (24) | 28 | NA | HOMA-IR, fasting insulin(–); Glucose/insulin ratio(+) | (–) | FAI(–); SHBG(+) |
| Yilmaz et al. (30) | 83 | (+) | HOMA-IR, fasting glucose, fasting insulin(NA) | NA | DHEA-SO4T, FAI, mFG-score(+); SHBG(–) |
(+), Positive correlation; (–), Negative correlation; NA, No association; \, Not mentioned; HOMA-IR, Homeostasis model assessment – Insulin resistance; T, Testosterone; TT, Total testosterone; HDL, High density lipoprotein; TG, Triglyceride; DHEAS, Dehydroepiandrosterone sulfate; FSH, Follicular stimulating hormone; RBP, Retinol-binding protein; SHBG, Sex hormone binding globulin; FAI, Free androgen index; mFG—score, modified Ferriman–Gallwey score.