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Histopathology of the skin and lung microvasculature in TBRIca-Cdh5-Cre transgenic mice. Skin sections (a) and lung sections (b) from control mice (left panel) and from TBRIca-Cdh5-Cre-tamoxifen-injected mice (two right panels). Note extensive collagen accumulation in the subendothelial space and surrounding vessels as well as marked narrowing with almost complete obliteration of vascular lumen by intensely staining collagen fibrotic tissue (magnification × 20).
