Table 1:
Overall % N=294 |
Unadjusted HR: 95% CI |
DBS FTC-TP Model AHR: 95% CI |
DBS TFV-DP Model AHR: 95% CI |
|
---|---|---|---|---|
Age at study entry, median (IQR)1 | 33 (27-42) | 0.79: 0.66-0.962 | 0.90: 0.71-1.152 | 0.82: 0.64-1.042 |
Race: White | 45 | Ref. | Ref. | Ref. |
Asian | 5 | 1.31: 0.56-3.05 | 1.42: 0.52-3.87 | 1.91: 0.71-5.12 |
Black | 13 | 1.73: 0.93-3.25 | 1.09: 0.49-2.44 | 0.89: 0.39-2.02 |
Latino | 32 | 1.78: 1.21-2.63 | 1.29: 0.65-2.53 | 1.36: 0.69-2.67 |
Mixed/other | 4 | 0.94: 0.34-2.60 | 1.62: 0.55-4.80 | 1.41: 0.48-4.20 |
Transwoman (vs. MSM) | 3 | 1.12: 0.28-4.54 | 0.87: 0.20-3.67 | 0.99: 0.24-4.11 |
Site: San Francisco | 36 | Ref. | Ref. | Ref. |
Miami | 31 | 2.37: 1.63-3.45 | 1.13: 0.59-2.18 | 1.15: 0.59-2.23 |
Washington D.C. | 32 | 0.92: 0.52-1.58 | 0.73: 0.38-1.40 | 0.78: 0.41-1.51 |
Sub-optimal adherence by TFV-DP (<700 fmol/punch) at any visit3 | 292 | 4.21: 2.57-6.903 | - | 4.31: 2.43-7.623 |
Undetectable DBS FTC-TP at any visit3 | 252 | 7.53: 4.81-11.783 | 6.27: 3.83-10.223 | - |
AHR: Adjusted hazard ratio; DBS: Dried Blood Spot; FTC-TP: emtricitabine-triphosphate; TFV-DP: tenofovir-diphosphate; CI: Confidence interval; IQR: inter-quartile range; MSM: Men who have sex with men.
Scaled per ten years
Lowest documented adherence during course of the demo project
Treated as a time-dependent covariate in survival analysis