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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Heart Lung. 2018 Oct 9;47(6):565–575. doi: 10.1016/j.hrtlng.2018.09.002

Figure 4: Relationships between sE-Selectin and Symptoms Comparing Moderate to Advanced Heart Failure.

Figure 4:

In each image, the symptoms are presented on the y-axis, the natural log of sE-Selectin (a metric of endothelial dysfunction) is presented on the x-axis (within the range observed in this study), results from the moderate heart failure cohort are represented by dashed lines with circles at the mean, and results from the advanced heart failure cohort are represented by solid gray lines with squares at the mean. Higher levels of sE-Selectin were associated with worse dyspnea in moderate heart failure, but were associated with less dyspnea in advanced heart failure (interaction p=0.034). Similarly, higher levels of sE-Selectin were associated with worse early & subtle symptoms in moderate heart failure but less early & subtle symptoms in advanced heart failure (interaction p=0.007). CI = confidence interval; sE-Selectin = soluble E-Selectin.