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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2018 Aug 8;1865(7):1865–1875. doi: 10.1016/j.bbadis.2018.08.011

Fig.1:

Fig.1:

Cumulative survival curve, aging markers, Akt isoforms and AMPKα2 expressions in WT and Akt2-AMPKα2 double knockout (DKO) mice. A: Representative gel blots depicting p16, p21, Akt1, Akt2, Akt3, AMPKα2 and GAPDH (loading control) levels using specific antibodies in 4- and 12 month-old mice; B: The Kaplan–Meier cumulative survival rate plotted against age in months in WT and DKO mice. The log-rank test was performed to compare the two curves (p = 0.3098). C: p16 expression; D: p21 expression; E: Akt1 expression; F: Akt2 expression; G: Akt3 expression; and H: AMPKα2 expression. Mean ± SEM, n = 29–30 mice per group for panel B; n = 3 mice per group for panel C-H, *p < 0.05 vs. WT-4 month-old group.