Table 1:

General characteristics of in 4 month-old and 12 month-old WT mice and Akt2 and AMPKα2 knockout (DKO) mice.

Parameter	WT-4 Mon	WT-12 Mon	DKO-4 Mon	DKO-12 Mon
Body Weight (BW, g)	25.9 ± 0.8	29.4 ± 0.4	22.9 ± 1.5	27.4 ± 1.5
Tibial Length (mm)	18.2 ± 0.4	20.7 ± 0.4*	17.0 ± 0.2	18.8 ± 0.5*
Heart Weight (HW, mg)	154 ± 5	165 ± 3	141 ± 10	192 ± 6*#
HW/BW (mg/g)	5.96 ± 0.21	5.63 ± 0.10	6.23 ± 0.39	7.12 ± 0.28*#
Liver Weight (LW, g)	1.27 ± 0.03	1.49 ± 0.02*	1.17 ± 0.06	1.31 ± 0.03#
LW/BW (mg/g)	49.2 ± 1.7	50.7 ± 1.0	51.6 ± 1.5	52.4 ± 2.0
Kidney Weight (KW, g)	0.312 ± 0.009	0.379 ± 0.006*	0.305 ± 0.005	0.369 ± 0.006*
KW/BW (mg/g)	12.1 ± 0.4	12.9 ± 0.3	13.8 ± 0.7	13.8 ± 0.6
Spleen Weight (SW, g)	0.087 ± 0.005	0.162 ± 0.006*	0.083 ± 0.004	0.162 ± 0.014*
Glucose (mg/dl)	97.8 ± 5.1	97.1 ± 5.0	99.9 ± 5.1	103.0 ± 5.8
Insulin (ng/ml)	0.094 ± 0.010	0.244 ± 0.023*	0.088 ± 0.010	0.272 ± 0.030*
Triglyceride (mg/dl)	69.4 ± 4.5	80.3 ± 4.1*	63.7 ± 6.3	88.1 ± 8.3*

Mean ± SEM, n = 6–10 mice per group,

^*p < 0.05 vs. WT-4 month group;

^#p < 0.05 vs. WT-12 month group.