Table 1. Descriptive baseline characteristics and findings of studies.
| Study | Year | Number of patients | Patient population | Type of surgery | Follow-up
duration |
Statin effect on
adverse outcome |
|---|---|---|---|---|---|---|
| Clinical trials | ||||||
| LOAD trial | 2016 | 648 | High-risk statin-naïve
patients |
Non-cardiac surgery | 30 days | No risk reduction |
| Xia et al. 17 | 2015 | 550 | Stable coronary artery
disease on long-term statin |
Non-cardiac | 6 months | Risk reduction |
| DECREASE-IV | 2009 | 1066 | Patients at intermediate
cardiac risk |
Non-cardiac | 34 days | No reduction |
| Meta-analysis | ||||||
| Hindler et al. 18 | 2006 | 223,010 (15 studies) | General patients | General surgery
including cardiac |
- | Risk reduction |
| Antoniou et al. 19 | 2015 | 22,681 (24 studies) | General patients | Vascular surgery | - | Risk reduction |
| Observational cohort | ||||||
| London et al. 20 | 2017 | 180,478 | General patients | Non-cardiac surgery | 30 days | Risk reduction |
| VISION cohort | 2016 | 15,487 | General patients | Non-cardiac surgery | 30 days | Risk reduction |
DECREASE-IV, Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echocardiography IV; LOAD, Lowering the Risk of Operative Complications Using Atorvastatin Loading Dose; VISION, Vascular Events in Noncardiac Surgery Patients Cohort Evaluation.