Table 2.
Overrepresented GO terms associated with IR-modulated exosome proteins
| GO Term ID | IR-upregulated | IR-downregulated | IR-unchanged | Enrichment | P-value |
|---|---|---|---|---|---|
| GO:2000377 [BP]: regulation of ROS metabolic process | ARF4; ASS1; HSP90AA1; HSP90AB1; PARK7; PID1; RAC1; RAC2; RGN; TP53 | SZT2 | AGT; APS; CAV1; CLU; EGFR; GSTP1; INSR; PTK2B | 1.48 | 0.04 |
| GO:0006281 [BP]: DNA repair | COPS2; ERCC5; HIST1H4A; HUWE1; POLI; RAD51D; RECQL5; RPS27A; RPS3; RUVBL1; SMC5; SPIDR; SYCP1; TP53; USP45; XRCC5; XRCC6 | BABAM1; FANCM; RUVBL2; SETMAR | ATXN3; BAF53A; BRCA2; CSPG3; EP300; HERC2; MCM9; NPM1; RECQL; RFC1; SMC1A; TAOK3; TICRR; USP7; VIL2 | 1.50 | 0.01 |
| GO:0006323 [BP]: DNA packaging | AKAP8L; HIST1H3A; HIST1H4A; HIST2H2BF; HIST2H3PS2; NAP1L1; RUVBL1; SET; SYCP1; TP53 | TTN | ASH1L; CENPV; CHMP1A; HIST1H1B; HIST1H1D; NPM1 | 1.65 | 0.03 |
| GO:0010212 [BP]: response to ionizing radiation | AEN; ANXA1; NIPBL; RAD51D; SPIDR; THBD; TP53; XRCC5; XRCC6 | BABAM1 | BRCA2; DNMT3A; INTS7; MYC; TICRR | 1.70 | 0.03 |
| GO:0006458 [BP]: ‘de novo’ protein folding | CCT2; CCT4; CCT6A; CCT7; CCT8; HSPA8; HSPD1 | FYCO1; TCP1 | 2.00 | 0.02 | |
| GO:0000785 [CC]: chromatin | AKAP8L; CENPF; CHD4; CTR9; EED; H2AFV; HIST1H2AC; HIST1H3A; HIST1H4A; HIST2H2BF; HIST2H3PS2; JMJD1C; NCOR1; NIPBL; PARK7; PAX6; RAN; RUVBL1; TP53 | RUVBL2; T | AHCTF1; ANKRD17; CSNK2B; CTNNB1; DNMT3A; EIF3E; HIST1H1B; HIST1H1D; HNRNPC; MBD1; MUC1; POLR3G; RB1; TCP1; UBA1; VIL2; ZNF385A | 1.43 | 0.02 |
| GO:0031597 [CC]: cytosolic proteasome complex | PSMC3; PSMC5; PSMC6; PSMD1; PSMD2 | – | PSMC2 | 2.16 | 0.03 |
| GO:0008026 [MF]: ATP-dependent helicase activity | ABP1; CHD4; DDX21; DHX9; RECQL5; RUVBL1; XRCC5; XRCC6 | DDX41; RUVBL2 | CHD3; DDX59; EIF4A1; RECQL; YTHDC2 | 1.73 | 0.03 |
Presented are Gene Ontology (GO) terms corresponding to Biological Processes (BPs), Molecular Functions (MFs), and Cellular Components (CCs); IR = ionizing radiation.