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. 2019 Apr 29;60(3):298–307. doi: 10.1093/jrr/rrz011

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© The Author(s) 2019. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 1. — Schematic of the proposed model in this study. (A) The dose–response curve hypothetically dividing two types of cell populations from one type of cell line: (i) a group including only radioresistant cells, and (ii) another group consisting of only non-radioresistant cells. (B) The dose–response curve of actual heterogeneous cell lines (iii), which include 1% radioresistant cells. In this study, radioresistant cells were regarded as CSCs. CSCs: cancer stem cells.