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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Diabetes Obes Metab. 2019 Mar 20;21(5):1088–1100. doi: 10.1111/dom.13641

Table 1.

Summary of common variants associations in major genes identified in GWAS of obesity showing pleiotropic association with two or more cardiovascular risk traits

Obesity Type 2 Diabetes Fasting Blood Glucose Dyslipidemia Hypertension
Gene/rs ID Popul ation Effect Allele Beta or OR P value N PMID OR P value N PMID Beta P value N PMID Beta P value N PMID Beta P value N PMID
ADAMTS9 rs6795735 EUR C 0.025 9.8×10−14 161,642 20935629 1.07 4.4×10−4 69,033 24509480 2.03‡ 0.042 77,167 20935629 −2.5‡ 0.013 77,167 20935629 --- --- --- ---
ADCY3 rs10182181 EUR G 0.031 8.8×10−24 322,154 25673413 1.0 0.89 86,188 25673413 6×10−4 0.77 131,771 25673413 0.009 0.049 172,937 25673413 0.14 0.023 67,936 25673413
ADCY3/ POMC rs713586 EUR C 0.14 6.2×10−22 230,748 20935630 − 0.833 10,128 20935630 0.004 0.44 5,641 27530450 − 0.45 19,000 20935630 --- --- --- ---
rs713586 EAS C 0.025 4.9×10−13 173,430 28892062 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
BDNF rs11030104 EUR A 1.05† 1.3×10−34 339,224 25673413 1.01 0.37 83,545 25673413 0.003 0.41 58,074 25673413 0.014 1.35×10−3 163,969 25673413 0.23 2.1×10−3 69,843 28135244
FTO rs9939609 EUR A 0.10‡ 3×10−35 30,081 17434869 1.25 1×10−20 63,961 22693455 0.69 0.012 9,618 27790247 --- --- --- --- 0.28 0.163 9,618 27790247
rs9939609 SAS A 1.25† 9×10−19 39,774 22109280 1.15 5.5×10−8 18,112 22109280 0.24 0.03 1,666 21294771 --- --- --- --- --- --- --- ---
rs9939609 EAS A 1.27† 1.2×10−13 9,035 22109280 1.15 2.43×10−7 59,106 22109280 --- --- --- --- --- --- --- --- --- --- --- ---
GIPR rs11671664 EUR A 0.029 0.0012 194,562 22344221 1.08 2.4×10−5 20,298 28869590 --- --- --- --- --- --- --- --- --- --- --- ---
rs11671664 SAS A --- --- --- --- 1.08 1.29×10−2 42,071 28869590 --- --- --- --- --- --- --- --- --- --- --- ---
rs11671664 EAS A 0.046 7×10−14 62,245 22344221 1.08 6.3×10−7 50,981 28869590 --- --- --- --- --- --- --- --- --- --- --- ---
GIPR rs10423928 EUR A 1.16† 4×10−13 95,632 23563607 1.07 1.8×10−4 57,599 20081857 0.08 2×10−15 41,099 20081857 --- --- --- --- --- --- --- ---
MC4R rs6567160 EUR C 0.056 3.9×10−53 321,958 25673413 1.07 6×10−7 80,620 25673413 0.003 0.196 128,057 25673413 -0.03 2.9×10−9 185,608 25673413 0 0.994 66,849 25673413
MC4R rs12970134 EUR A 1.12† 9.9×10−16 51,151 23049848 1.26 0.006 4,561 18454146 0.004 0.083 889 21372613 -1.34 0.01 4,561 18454146 0.11 0.64 4,561 18454146
rs12970134 SAS A 0.004 6.8×10−4 7,394 18454146 1.07 0.15 7,394 18454146 --- --- --- --- -0.76 0.03 7,394 18454146 -0.06 0.71 7,394 18454146
rs12970134 SAS- Sikhs A 0.67 0.0005 1,528 19680233 --- --- --- --- --- --- --- --- 0.01 0.97 1,528 19680233 --- --- --- ---
PCSK1 rs6234/ rs6235 EUR G 1.09† 1.25×10−5 163,385 25784503 --- --- --- --- −0.01 1.4×10−6 1,367 23903356 --- --- --- --- --- --- --- ---
rs6234/ rs6235 EAS G 1.0† 0.274 66,721 25784503 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
PEMT rs4646404 EUR G 0.027 1.4×10−11 198,196 27195708 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
rs4646404 SAS G -0.03 0.1 9,505 27195708 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
POMC rs1561288 EUR C 0.055 5×10−8 28,998 23669352 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
SH2B1 rs7359397 EUR T 0.15 1.9×10−20 204,309 20935630 + 0.306 10,128 20935630 0.018 9.8×10−4 5,641 27530450 - 0.099 19,000 20935630 --- --- --- ---
SH2B1 rs7498665 EUR G 0.15 5.1×10−11 86,677 19079261 1.09 2.5×10−6 70,930 24528214 --- --- --- --- --- --- --- --- --- --- --- ---
rs7498665 EAS G --- --- --- --- 1.11 0.179 21,793 24528214 --- --- --- --- --- --- --- --- --- --- --- ---
TBX15- WARS2 rs2645294 EUR T 0.031 1.7×10−19 209,808 25673412 --- --- --- --- -0.09 0.014 770 28257690 0.155 1.6×10−5 770 28257690 -0.12 8.3×10−4 770 28257690

+/−: Effect Direction

†

OR Values

‡

Z score

N: Sample Size; PMID: PubMed ID; EUR: European; EAS: East Asian; SAS: South Asian