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. 2017 Nov 6;26(3):186–190. doi: 10.1016/j.tim.2017.10.004

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© 2017 Elsevier Ltd. All rights reserved.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Antibody-Dependent Enhancement (ADE) of Dengue and Zika Virus. ADE during a secondary heterologous Dengue virus infection has been documented in vitro, in mice, in non-human primates, and in humans playing a key role in the worsening of the clinical presentations. In contrast, ADE of Zika virus by pre-existing immunity to Dengue virus can be induced in vitro, and in immunodeficient mice. However, there is no evidence to support ADE occurring in non-human primates or in humans.