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. Author manuscript; available in PMC: 2019 May 22.
Published in final edited form as: ACS Appl Mater Interfaces. 2018 Sep 17;10(38):31915–31927. doi: 10.1021/acsami.8b09642

Figure 1.

Figure 1

(A) Illustration of a CLPBAP polyplex for the delivery of various negatively charged payloads. (B) Chemical structures of the PBAP-based polymers used to form crosslinked polyplexes including CLPBAP polymers (i.e., p(BAC-TET-Im/AD) and p(BAC-TET-Im/β-CD)), and PEG–p(BAC-TET-Im/AD)–PEG. (C) Chemical structures of the PBAP-based polymers used to prepare non-crosslinked PBAP polyplexes including the PBAP polymer (i.e., p(BAC-TET-Im)) and PEG–p(BAC-TET-Im)–PEG. (D) Formation of the crosslinked CLPBAP polyplexes and their proposed intracellular trafficking pathways. CLPBAP: crosslinked poly(N,N’-bis(acryloyl)cystamine-poly(aminoalkyl)); p(BAC-TET): poly(N,N’-bis(acryloyl)cystamine-co-triethylenetetramine; Im:imidazole; AD: adamantane; β-CD: β-cyclodextrin; PEG: poly(ethylene glycol, Mw = 5000 Da); GSH: glutathione