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. Author manuscript; available in PMC: 2019 May 22.
Published in final edited form as: ACS Infect Dis. 2017 Oct 18;4(1):59–67. doi: 10.1021/acsinfecdis.7b00105

Fig. 5. Cytological profiling reveals clustering of phocoenamicin with ionophores.

Fig. 5.

(A) Hierarchical clustering of 5,000 compound treated wells evaluated against 248 cellular features. Positive and negative deviations relative to DMSO controls represented in yellow and blue, respectively. (B) Fluorescence images of drug-treated wells (phocoenamicin 146 μM, monensin 9.6 μM). Tubulin is represented in green, mitotic cells in cyan, actin in red, and DNA in blue. (C) Expanded fingerprints of phocoenamicin and neighboring cluster, which is enriched for ionophores.