Table 1:
Demographic data and disease characteristics distributed among the MCL35 risk groups
| Patient Demographic Data and Disease Characteristics | |||||
|---|---|---|---|---|---|
| Variable | Total Cohort, n (%) | Low Risk Group n (%) | Standard-Risk Group n (%) | High-Risk Group n (%) | P |
| Assessable patients | 74 | 27 (36) | 29 (39) | 18 (24) | 1 |
| Male | 64 (86) | 23 (85) | 25 (86) | 16 (89) | |
| Female | 10 (14) | 4 (15) | 4 –(14) | –2 (11) | |
| Median age, years (range) | 59 (41–67) | 60 (45–67) | 58 (41–67) | 60.5 (43–65) | |
| > 65 | 2 | 1 | 1 | 0 | |
| Clinical features | |||||
| ECOG performance stat | |||||
| 0–1 | 68 (92) | 26 (96) | 27 (93) | 15 (83) | 0.32 |
| 2–4 | 6 (8) | 1 (4) | 2 (7) | 3 (7) | |
| Missing | |||||
| White cell count, median (range) | 6.8 (3.4–56.2) | 6,3 (4.2–20.5) | 7,2 (3.4–56.2) | 8,4 (4.4–18.2) | 0.31 |
| Bone marrow infiltration | 59 (80) | 24 (89) | 19 (66) | 16 (89) | 0.051 |
| LDH | |||||
| Normal | 35 (47) | 16 (59) | 15 (52) | 4 (25) | 0.043 |
| >ULN | 39 (53) | 11 (41) | 14 (48) | 14 (75) | |
| MIPI | |||||
| Low < 5.7 | 36 (49) | 15 (56) | 14 (48) | 7 (39) | 0.81 |
| Intermediate (5.7–6.2 | 26 (35) | 9 (33) | 10 (35) | 7 (39) | |
| High (>= 6.2) | 12 (16) | 3 (11) | 5 (17) | 4 (27) | |
| MIPI – c | |||||
| Low | 25 (34) | 13 (48) | 10 (35) | 2 (11) | 0.16 |
| Low-intermediate | 22 (30) | 8 (30) | 8 (28) | 6 (33) | |
| High-intermediate | 19 (26) | 5 (19) | 8 (28) | 6 (33) | |
| High | 8 (11) | 1 (4) | 3 (10) | 4 (22) | |
| Ki67 proliferation index | |||||
| < 30 | 40 (54) | 21 (78) | 16 (55) | 3 (17) | <0.001 |
| >=30 | 34 (46) | 6 (12) | 13 (45) | 15 (83) | |
| MIPI-B | |||||
| Low < 5.7 | 9 (12) | 5 (19) | 3 (10) | 1 (6) | 0.064 |
| Intermediate 5.7–6.5 | 37 (50) | 15 (56) | 17 (59) | 5 (28) | |
| High >= 6.5 | 28 (38) | 7 (26) | 9 (31) | 12 (67) | |
| Pathology | |||||
| Classic | 54 (73) | 25 (93) | 23 (80) | 6 (33) | <0.001 |
| Blastic (pleomorphic, blastoid) | 20 (27) | 2 (7) | 6 (21) | 12 (67) | |
| Given HDT with BEAM | 68 (92) | 24 (89) | 27 (93) | 17 (94) | |
| Reason not given HDT | |||||
| Toxicity | 1 | 1 | |||
| Harvest failure | 2 | 1 | 1 | ||
| Stage I | 1 | 1 | |||
| Age | 1 | 1 | |||
| No response induction | 1 | 1 | |||
| CR | 66 (90) | 24 (90) | 26 (90) | 16 (90) | 0.92 |
| CR / PR | 72 (98) | 26 (97) | 28 (97) | 18 (100) | |