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. 2019 May 14;2(6):350–355. doi: 10.1017/cts.2019.3

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© The Association for Clinical and Translational Science 2019

This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is unaltered and is properly cited. The written permission of Cambridge University Press must be obtained for commercial re-use or in order to create a derivative work.

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Fig. 1. — Domain structure of A20 and SNP locations.

Note: The N-terminal ovarian tumor-like unit (OTU) domain contains the catalytic triad of aspartate (D70), cysteine (C103), and histidine (H256). Seven zinc-fingers (ZnF1-ZnF7) are located in the C-terminal portion of the protein. The E3 ligase function of A20 is contained within ZnF4, while the linear ubiquitin binding function is dependent upon ZnF7. Both rs146534657 (N102S) and rs2230926 (F127C) are located with the N-terminal OTU domain.