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. Author manuscript; available in PMC: 2019 May 22.
Published in final edited form as: Curr Opin Chem Eng. 2018 Mar 6;19:142–152. doi: 10.1016/j.coche.2018.01.003

Figure 2. Integrated and dynamic profiling of T cells.

Figure 2

T cells are capable of many different functions and integrate cues from both the cells and soluble factors from the microenvironment to facilitate decision-making. A complete understanding of T cells can be only accomplished by tracking dynamically cell-cell interactions (e.g. synapse formation, cytotoxicity), intrinsic and chemokine guided motility, cytokine secretion, bioenergetics, transcriptome, morphology, differentiation status and proliferation or survival. Assays that are able to provide insights into one or more of these features on the same cells, at single-cell resolution, can provide a deeper understanding of the underlying biology.