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. 2019 May 1;30(3):177–185. doi: 10.1097/MOL.0000000000000602

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Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc.

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0

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Potential mechanisms by which senescent cells contribute to adipose tissue dysfunction. Healthy adipose tissue is able to adapt to nutrient availability and environmental changes through adipogenesis providing metabolic flexibility. Senescent cell accumulation leads to increased secretion of SASP factors which can attract immune cells leading to low grade inflammation, insulin resistance and decreased formation of white and beige adipocytes. These changes can disturb systemic metabolic homeostasis. This figure was created using Servier Medical Art (http://smart.servier.com/).